Breast cancer is an uncontrolled growth of breast cells that occurs as a result of mutations in the genes responsible for regulating cell growth and health. These genetically mutated cells gain the ability to continuously divide without control or order, eventually resulting in a tumor. The term “breast cancer” refers to a cancerous or malignant tumor that has developed from cells in the lobules or ducts of the breast. Breast cancer is not a single disease, but a group of diseases that are related because they involve tissues of the breast.
Anyone with breast tissue can develop breast cancer, although women are at greater risk than men. Individual risk increases with age and is affected by factors such as family and reproductive history, lifestyle, and environment. According to the American Cancer Society, about 1 in 8 U.S. women (or 12 percent) will develop invasive breast cancer. In 2015, an estimated 231,840 new cases of invasive breast cancer and 60,290 new cases of non-invasive breast cancer are expected to be diagnosed in women in the U.S.
Death rates from this disease exceed those of all other cancers except lung cancer. About 40,000 women in the U.S. are expected to die in 2015 from breast cancer, though death rates have been decreasing as a result of treatment advances, earlier detection through screening, and increased awareness.
Novare peptide therapeutics may offer new hope for breast cancer patients in several different ways. First, RHAMM is over-expressed in breast cancer and its expression in triple negative (TNBC) and HER2 subtypes is associated with poor outcomes. Therefore, blocking RHAMM with a Novare peptide in TNBC and HER2 patients may improve outcomes. Also, Novare peptides may prevent or reduce the scarring of non-target tissue that results from radiation treatment of breast cancer patients, an ancillary effect of which is reduced breast cancer recurrence. Furthermore, under certain conditions, Novare peptides are adipogenic and could prove useful for generating fat tissue for breast reconstruction following mastectomy.