Subcutaneous Fat Layer in Normal Skin
Subcutaneous Fat Layer in Normal Skin
RHAMM-Peptide-Enhanced Subcutaneous Fat Layer
RHAMM-Peptide-Enhanced Subcutaneous Fat Layer

RHAMM, or Receptor for Hyaluronan-Mediated Motility, is a protein that is localized outside of as well as within cells and plays a role in the regulation of cell movement and mesenchymal stem cell differentiation. Research by oncology scientist Dr. Eva Turley and her colleagues found that blocking RHAMM provides the safest and most efficacious means to selectively stimulate subcutaneous fat growth (adipogenesis), moderate destructive inflammation, and reduce scarring (fibrosis) by controlling the body’s own natural regenerative processes.

RHAMM-Peptide-Regenerated Cartilage
RHAMM-Peptide-Regenerated Cartilage

This provides Novare with a significant opportunity to find treatments for a variety of inflammatory conditions including Bronchopulmonary Dysplasia (BPD) in premature infants and arthritis, and for fibrotic diseases such as Idiopathic Pulmonary Fibrosis (IPF). It can promote scarless healing for post-surgical wounds as well as the reduction — or even elimination — of keloids (excess scarring).

Normal Breast Tissue
Normal Breast Tissue
Post-Mastectomy
Post-Mastectomy
RHAMM-Peptide-Regenerated Breast Tissue
RHAMM-Peptide-Regenerated Breast Tissue

This breakthrough in tissue engineering and disease control also holds the promise of regeneration and reconstruction of women’s breasts by localized stimulation of the body’s own adipocyte stem cells after a mastectomy.

The studies conducted to date are reproducible and demonstrate medically relevant, drug-induced biological responses. Novare has acquired the exclusive rights to this revolutionary technology discovered by Dr. Eva Turley and her colleagues at several academic organizations including Lawrence Berkeley National Laboratory and the Lawson Health Research Institute.

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